Endocrine Abstracts

Aim: Acromegaly is associated with premature dead and a number of risk factors for cardiovascular disease (CVD). We aimed to examine the concept of cumulative GH exposure with regard to the presence these risk factors and cancer in acromegalic patients.Methods: Retrospective observational study in all acromegalic patients from 2006 to 2017 with a minimum of 3 years of follow-up. We exclude patients not treated. GH exposure was calculated as median GH or ...

BackgroundEndogenous Cushing’s syndrome (CS) is detrimental to bone. The skeletal complications are characterized by decreased bone formation and increased bone resorption, resulting in decreased bone mineral density (BMD) and an increased risk of fractures at time of diagnosis. After remission of the disease, BMD improves towards normal values but fracture rate remains elevated. Therefore, components of bone quality other than BMD, such as bone mat...

Thyroid cancer is the most common type of endocrine tumor and reaches the peak of incidence between the age of twenty and fifty years. It has 4-fold higher prevalence in females than males, suggesting that estrogens and their receptors could be involved in thyroid cancer pathogenesis. Previous studies demonstrated allosteric interference operated by G protein-coupled estrogen receptor (GPER) to molecules structurally similar to the thyroid-stimulating hormone (TSH) receptor (T...

Background: Follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) are expressed on the surface of granulosa cells, where they form heteromeric complexes, shifting FSH-induced signals to survival pathways and determining the follicular fate.Objectives: We evaluated whether GPER can interact with the luteinizing hormone (LH)/choriogonadotropin (hCG) receptor (LHCGR) and modulate the LH/hCG/dependent signalling pathways...

Background: Testis stimulation with follicle stimulating hormone (FSH) is one of the empirical treatments proposed for male idiopathic infertility, although early reliable markers to predict its efficacy are still lacking.Objective: To identify the improvement of semen parameters required to predict a priori FSH efficacy in terms of pregnancy achievement.Methods: A real-world study was conducted, enrolling idiopathic infer...

Background: Despite male idiopathic infertility is characterized by semen analysis alteration with gonadotropins within reference ranges, it is still considered a functional hypogonadotropic hypogonadism (FHH). This simple definition is fundamental to guide the empirical therapeutic approach of these men. However, the number of studies describing total testosterone serum levels (TT) in male idiopathic infertility is still limited.Objective: To evaluate T...

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease and Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid injury. From a neuropsychological standpoint, patients with PS-HypoPT present cognitive and neuropsychological symptoms. Irisin is a myokine secreted by contracting muscle, which mediates beneficial effects on several targets, including brain. The aim of this study was to evaluate irisin in the context of PS-HypoP...

Serous ovarian cancer is one of the leading causes of death among all gynaecological malignancies. Even though a hereditary component has been suggested, most ovarian carcinomas are sporadic and markers for a diagnosis at an early stage of the disease are still to be identified. Since gonadotropins may stimulate the growth of certain cancer cells, we aim to identify tumour markers linked to gonadotropin receptor-mediated pathways. Through an in silico and ex vivo<...

Beckgrounds and aims: The most common cause of hypoparathyroidism is postoperative, i.e., after thyroid, parathyroid, or radical neck surgery due to neoplasms, and is most often transient, whether continuous or even intermittent. The incidence of permanent hypoparathyroidism ranges from 0.8 to 3.0% in patients after total thyroidectomy. In this case report, we will present a patient with a severe form of postoperative hypoparathyroidism refractory to standard treatment regimen...

Perinatal maternal high-fat (HF) and isocaloric diet induced obesity and metabolic disorders in the offspring since weaning. At adulthood, oxidative soleus skeletal muscle of HF male offspring exhibited lipid accumulation and mitochondrial damage. At birth, HF offspring have higher n-6:n-3 polyunsaturated fatty acids (PUFA) plasma ratio. We hypothesized that HF offspring´s mitochondria of skeletal muscle exhibit damages at weaning that could be mitigated by fish oil (FO, ...